Multiple Molecular Imaging Research Laboratory



A. Fukunaka, Y. Kurokawa, F. Teranishi, I. Sekler, K. Oda, M.L. Ackland, V. Faundez, M. Hiromura, S. Masuda, M. Nagao, S. Enomoto, T. Kambe, Tissue non-specific alkaline phosphatase is activated via a two-step mechanism by zinc transporter complexes in the early secretory pathway, J. Biol. Chem., in press.
T. Fukuchi, Y. Arai, F. Watanabe, S. Motomura, S. Takeda, Y. Kanayama, H. Haba, Y. Watanabe, S. Enomoto.
A Digital Signal Processing Module for Ge Semiconductor Detectors. IEEE Transactions on Nuclear Science, in press.
M. Kidera, Y. Seto, K. Takahashi, S. Enomoto, S. Kishi, M. Makita, T. Nagamatsu, T. Tanaka, M. Toda.
New method for comprehensive detection of chemical warfare agents using an electron-cyclotron-resonance ion-source mass spectrometer, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 78(3), 1215-1219(2011).
H. Fujishiro, K. Kubota, D. Inoue, A. Inoue, T. Yanagiya, S. Enomoto, S. Himeno.
Cross-resistance of cadmium-resistant cells to manganese is associated with reduced accumulation of both cadmium and manganese
Toxicology, 280(3), 118-125 (2011).
F. Yatagai, M. Honma, A. Takahashi, K. Omori, H. Suzuki, T. Shimazu, M. Seki, T. Hashizume, A. Ukai, K. Sugasawa, T. Abe, N. Dohmae, S. Enomoto, T. Ohnishi, A. Gordon, N. Ishioka.
Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation.
Radiation and Environmental Biophysics, 50, 125–134 (2011).
T. Yoshimura, H. Kikunaka, H. Haba, S. Enomoto, N. Takahashi, A. Shinohara.
Separation of Americium(III), Curium(III), and Californium(III) Using Capillary Electrophoresis.
Radiochimica Acta, in press.
F Ohsawa, K Morishita, S Yamada, M Makishima, H Kakuta.
Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers.
ACS Med. Chem. Lett., 1:(9), 521–525(2010).
S. Kamino, Y. Horio, S. Komeda, K. Minoura, H. Ichikawa, J. Horigome, A. Tatsumi, S. Kaji, T. Yamaguchi, Y. Usami, S. Hirota, S. Enomoto, Y. Fujita,
A new class of rhodamine luminophores: design, syntheses and aggregation-induced emission enhancement
Chem. Commun., 46, 9013-9015 (2010).
N. Kamei, M. Morishita, Y. Kanayama, K. Hasegawa, M. Nishimura, E. Hayashinaka, Y. Wada, Y. Watanabe, K. Takayama
Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography
Journal of Controlled Release, 146,1, 16-22 (2010)
S. Takeda, H. Odaka, J. Katsuta, S. Ishikawa, S. Sugimoto, Y. Koseki, S. Watanabe, G. Sato, M. Kokubun, T. Takahashi, K. Nakazawa, Y. Fukazawa, H. Tajima, H. Toyokawa.
Polarimetric performance of Si/CdTe semiconductor Compton camera
NIMA, 622, 619-627 (2010)
S Yamada, F Ohsawa, S Fujii, R Shinozaki, M Makishima, H Naitou, S Enomoto, A Tai, H Kakuta
Fluorescent retinoid X receptor ligands for fluorescence polarization assay
Bioorg. Med. Chem. Lett., 20(17), 5143-6 (2010)
S Fujii, F Ohsawa, S Yamada, R Shinozaki, R Fukai, M Makishima, S Enomoto, A Tai, H Kakuta.
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation.
Bioorg. Med. Chem. Lett. 20(17), 5139-42 (2010)
H Kakuta, R Fukai, Z Xiaoxia, F Ohsawa, T Bamba, K Hirata, A Tai
Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor
Bioorg. Med. Chem. Lett., 20(6), 1840-3(2010)
N. Suzaki, S. Kadi, K. Miyachi, K. Moriyama, S. Kamino, T. Yamaguchi, Y. Fujita
Spectrophotometric Determination of Chlorpromazine in Preparation with o-Sulfophenylfluorone and Gallium(III)
BUNSEKI KAGAKU, 59, 727-732 (2010)
Hori T, Masue T, Odahara A, Kura K, Tajiri K, Shimoda T, Fukuchi T, Suzuki T, Wakabayashi Y, Gono Y, Ogawa K
β decay of the 21/2+ isomer in 93Mo and level structure of 93Nb
Physical Review C, 80, 034306, 1-5 (2009)
M Hiromura, Y Adachi, M Machida, M Hattori, H Sakurai
Glucose lowering activity by oral administration of bis(allixinato)oxidovanadium(IV) complex in streptozotocin-induced diabetic mice and gene expression profiling in their skeletal muscles
Metallomics, 1(1), 92-100 (2009)
F Yatagai, A Takahashi, M Honma, H Suzuki, K Omori, M Seki, T Hashizume, T Shimazu, S Enomoto, T Ohnishi, N Ishioka,
LOH analyses for biological effects of space radiation: Human cell culture in "Kibo" of International Space Station
Biological Sciences in Space, 23(1), 11-16 (2009)
H Fujishiro, S Okugaki, S Yasumitsu, S Enomoto, S Himeno
Involvement of DNA hypermethylation in down-regulation of the zinc transporter ZIP8 in cadmium-resistant metallothionein-null cells
Toxicology and Applied Pharmacology, 241, 195–201 (2009)
Fumio Yatagai, Kaoru Sugasawa, Shuichi Enomoto and Masamitsu Honma
An Approach to Estimate Radioadaptation fromDSB Repair Efficiency
J. Radiat. Res., 50, 407–413 (2009)
Motomura.S, Fukuchi.T, Kanayama.Y, Haba.H, Watanabe.Y, Enomoto.S
Three-dimensional tomographic imaging by semiconductor Compton camera GREI for multiple molecular simultaneous imaging
2009 IEEE Nuclear Science Symposium Conference Record, Orlando, USA, 2009 10, IEEE, USA Piscataway, 3330-3332 (2009)
S Motomura, Y Kanayama, H Haba, K Igarashi, Y Watanabe, S Enomoto
Development of multielemental imaging on semiconductor Compton telescope
Pure Appl. Chem., 80(12), 2657–2666 (2008)
S Motomura, Y Kanayama, H Haba, Y Watanabe, S Enomoto
Multiple molecular simultaneous imaging in a live mouse using semiconductor Compton camera
J. Anal. At. Spectrom., 23, 1089-1092 (2008)
Hiromura M, Sakurai H
Action mechanism of insulin-mimetic vanadyl-allixin complex
Chemistry& Biodiversity 5(8), 1615-1621 (2008)
Nakayama A, Hiromura M, Adachi Y, Sakurai H
Molecular mechanism of antidiabetic zinc-allixin complexes: regulations of glucose utilization and lipid metabolism
Journal of Biological Inorganic Chemistry, 13(5), 675-684 (2008)
Hiromura M, Nakayama A, Adachi Y, Doi M, Sakurai H
Action mechanism of bis(allixinato)oxovanadium(IV) as a novel potent insulin-mimetic complex: regulation of GLUT4 translocation and FoxO1 transcription factor
Journal of Biological Inorganic Chemistry,12(8), 1275-1287 (2007)
Kidera M, Takahashi K, Enomoto S, Goto A, and Yano Y.
New fragment ion production method using super cold electrons in electron cyclotron resonance plasma
Euro. J. Mass Spectrom., 13(5), 355-358 (2007)
Kidera M, Takahashi K, Enomoto S, Mitsubori Y, Goto A, and Yano Y.
Development of a novel mass spectrometer equipped with an electron cyclotron resonance ion source
Euro. J. Mass Spectrom., 13(4), 239-248 (2007)
Minayoshi R., Ohyama T., Kinugawa N., Kamishima J., Ogi T., Ishikawa K., Noguchi M., Suganuma H., Takahashi K., Enomoto S. and Yanaga M
Change of concentrations of trace elements and protein contents in the liver of zinc deficient mice
Journal of Radioanalytical and Nuclear Chemistry, 272(2), 429-431 (2007)
Y Yamashita, Y Takahashi, H Haba, S Enomoto, H Shimizu
Comparison of reductive accumulation of Re and Os in seawater - sediment systems
Geochimica et Cosmochimica Acta, 71 (14) 3458-3475 (2007)
Motomura S, Kanayama Y, Haba H, Watanabe Y, Enomoto S
Multiple Nuclide Imaging in Live Mouse Using Semiconductor Compton Camera for Multiple Molecular Imaging
IEEE Nuclear Science Symposium Conference Record, Honolulu, USA, 2007年10-11月, IEEE, USA, Piscataway, 3741-3742 (2007)
Takahashi M., Suzuki T., Yumoto A., Togawa T., Haba H., Enomoto S., Nishio K., Tanabe S
Analysis of cisplatin behavior in a non-small cell lung cancer (NSCLC) cell line
Biomedical Research on Trace Elements, 17(3), 332-334, (2006)
K Igarashi, Y Nakanishi, R Hirunuma, S Enomoto, S Kimura
Multitracer study on the uptake of various trace elements in anemic rats: influence of NaFeEDTA and ferrous sulfate
Nutrition Research, 26, 173-179 (2006)
Asano N., Kondoh M., Ebihara C., Fujii M., Nakanishi T., Utoguchi N., Enomoto S., Tanaka K., Watanabe Y
Induction of zinc transporters by forskolin in human trophoblast BeWo cells
Reproductive Toxicology, 21, 285-291 (2006)
Kidera M., Nakagawa T., Takahashi K., Enomoto S., Igarashi K., Fujimaki M., Ikezawa E., Kamigaito O., Kase M., Goto A., Yano Y.
Improvement of trace element analysis system using RIKEN electron cyclotron resonance ion source and linear accelerator
Review of Scientific Instruments, 77, 373-375 (2006)
Kanayama Y., Enomoto S., Irie T., Amano R.
Axonal transport of rubidium and thallium in the olfactory nerve of mice
Nucl. Med. Biol., 32, 505-512 (2005)
Mitsunobu S., Takahashi Y., Hirunuma R., Haba H., Enomoto S.
Coupling of ICP-MS and multitracer technique as a new method to investigate dynamics of various elements in soil-water system
Chem. Lett., 34, 980-981 (2005)
Haba H., Kaji D., Kanayama Y., Igarashi K., and Enomoto S
Development of a gas-jet-coupled multitarget system for multitracer production
Radiochim. Acta, 93, 539–542 (2005)
Kanayama Y., Tsuji T., Enomoto S., Amano R
Multitracer screening: Brain delivery of trace elements by eight different administration methods
BioMetals, 18, 553-565 (2005)
Nagame Y., Tsukada K., Asai M., Toyoshima A., Akiyama K., Ishii Y., Kaneko-Sato T., Hirata M., Nishinaka I., Ichikawa S., Haba H., Enomoto S., Matsuo K., Saika D., Kitamoto Y., Hasegawa H., Tani Y., Sato W., Shinohara A., Ito M., Saito J., Goto S., Kudo H., Kikunaga H., Kinoshita N., Yokoyama A., Sueki K., Oura Y., Nakahara H., Sakama M., Schadel M., Bruchle W., Kratz JV.
Chemical studies on rutherfordium (Rf) at JAERI, Radiochimica Acta, 93, 519-526 (2005)
Matsumoto K., Hirunuma R., Enomoto S., Endo K.
In vivo multitracer analysis technique: Screening of radioactive probes for noninvasive measurement of physiological functions in experimental animals
Biol. Pharm. Bull., 28, 2029-2034 (2005)
S Enomoto
Development of Multitracer Technology and Application Studies on Biotrace Element Research
Biomed. Res. Trace Elem., 16, 233-240 (2005)

Conference Presentations

Shuichi Enomoto, "Semiconductor compton camera for multiple molecular imaging", The Eighth China-Japan Joint Seminar on Radiopharmaceutical Chemistry (CJSRC2010), Beijing, China
Enomoto S, "Development of multi-elemental molecular imaging on semiconductor compton telescope" 4th International Symposium on Commemoration of Exchange Agreement between National Taiwan University and Okayama University, Okayama, Japan
S.Enomoto, "Multi-molecular Imaging by Using Compton Telescope as a New Tool for Nuclear Medical Diagnosis" 2nd Asian Congress of Radiation Research (ACRR 2009) Seoul, Korea
S. Motomura: "Sophistication of Semiconductor Compton Camera towards Practical Multiple Molecular Simultaneous Imaging", Molecular Imaging 2008 Breaking New Ground in Drug Discovery and PET Diagnosis, Kobe, Japan
S. Enomoto: "Multiple Molecular Imaging Using the γ-Ray Emission Imaging GREI as a Tool for Metallomics Researches", 4th International Conference on Metals and Genetics, Paris, France.
S. Enomoto: "Development and Application Studies of Multitracer Technology", 6th International Conference on Isotopes, Seoul, Korea.
Shuichi Enomoto, "Development of Multi-Elemental Molecular Imaging on Semiconductor Compton Telescope", International Symposium on Metallomics, Nagoya, Japan

Press Releases

Feb 15, 2011
Development of a New Class of Organic Dyes with Aggregation-Induced Fluorescence: An Approach toward High-Signal-Output Nanoprobes for Protein Misfolding Diseases Bioimaging.
July 3, 2008
A Compton camera succeeded in the world's first simultaneous imaging of multiple radioactive agents in a living mouse.

Honors and Awards

S. Motomura: RIKEN Research Incentive Awards “Development of Advanced Molecular Imaging Technology with Semiconductor Compton Camera GREI”
S. Enomoto: The Pharmaceutical Society of Japan Award for Divisional Scientific Promotions “Establishment of the multi-tracer technology as a tool for analytical method of multi-elemental simultaneous metabolisms and developments of new analytical technologies”
The 44th Erwin von Bälz Prize, First Prize
Japan Society for Biomedical Research on Trace Elements Award