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分子プローブ動態応用研究チーム[Molecular Probe Dynamics Laboratory]　チームリーダー：渡辺 恭良
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主要な業績

論文

Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K., and Watanabe, Y.
Relationship between cognitive functions and prevalence of fatigue in elementary and junior high school students
Brain Dev.,in press (2010)
Mizuno, K., Tanaka, M., Fukuda, S., Sasabe, T., Imai-Matsumura, K., and Watanabe, Y.
Changes in cognitive functions of students in the transitional period from elementary school to junior high school
Brain Dev., 33(5):412-20 (2010)
Mizuno, K., Tanaka, M., Tajima, K., Okada, N., Rokushima, K., and Watanbe, Y.
Effects of mild-stream bathing on recovery from mental fatigue
Med. Sci. Monit., 16, CR8-CR14 (2010)
Tanaka, M., Mizuno, K., Fukuda, S., and Watanabe, Y.
Personality and fatigue in medical students
Psychol. Rep., 106, 567-575 (2010)
Takashima, T., Nagata, H., Nakae, T., Cui, Y., Wada, Y., Kitamura, S., Doi, H., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y., Watanabe, Y.
PET studies using 15R-[11C] TIC-Me for the evaluation of hepatobiliary transport.
J Pharmacol Exp Ther. 2010 Aug 17. in press
Tanaka, K., Siwu, Eric R. O., Minami, K., Hasegawa, K., Nozaki, S., Kanayama, Y., Koyama, K., Chen, Weihsu C., Paulson, J. C., Watanabe, Y., and Fukase, K.
Noninvasive Imaging of Dendrimer-Type N-Glycan Clusters: In Vivo Dynamics Dependence on Oligosaccharide Structure.
Angewandte Chemie, International Edition. in press.
Kamei, N., Morishita, M., Kanayama, Y., Hasegawa, K., Nishimura, M., Hayashinaka, E., Wada, Y., Watanabe, Y., and Takayama, K.
Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography.
Journal of Controlled Release. 146(1), 16-22, (2010)
高島 忠之、長田 浩子、橋爪 良信、土居 久志、中江 崇敬、和田 康弘、崔翼龍、鈴木 正昭、北村 吏司、前田 和哉、楠原 洋之、杉山 雄一、渡辺 恭良
15R-[11C]TICを用いたPositron Emission Tomography(PET)による肝胆系輸送の機能評価 薬理と治療
(JPT) 2009; 37 Suppl 1
Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, ER., Nozaki, S., Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., Fukase, K.
Electrocyclization-based labeling allows efficient in vivo imaging of cellular trafficking.
ChemMedChem. ;5(6), 841-5 (2010)
Nozaki S, Mizuma H, Tanaka M, Jin G, Tahara T, Mizuno K, Yamato M, Okuyama K, Eguchi A, Akimoto K, Kitayoshi T, Mochizuki-Oda N, Kataoka Y, Watanabe Y.
Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats.
Nutr Res. ;29(12), 867-72 (2009)
Nozaki, S., Tanaka, M., Mizuno, K., Ataka, S., Mizuma, H., Tahara, T., Sugino, T., Shirai, T., Eguchi, A., Okuyama, K., Yoshida, K., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe, Y.
Mental and physical fatigue-related biochemical alterations.
Nutrition. ;25(1), 51-57 (2009)
Tanaka, M., Mizuno, K., Tajima, S., Sasabe, T., and Watanabe, Y.
Central nervous system fatigue alters autonomic nerve activity
Life Sci., 84, 235-239 (2009)
Tanaka, M., Mizuno, K., Fukuda, S., Shigihara, Y., Tajima, S., and Watanabe, Y.
Personality traits associated with intrinsic academic motivation in medical students.
Med. Educ., 43, 384-387 (2009)
Mizuno, K., Tanaka, M., Ishii, A., Tanabe, C.H., Onoe, H., Sadato, N., and Watanabe, Y.
The neural basis of academic achievement motivation.
NeuroImage, 42, 369-378 (2008)
Mizuno, K., Tanaka, M., Nozaki, S., Mizuma, H., Ataka, S., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y.
Antifatigue effects of coenzyme Q10 during physical fatigue.
Nutrition, 24, 293-299 (2008)
Hasegawa, K., Kanayama, Y., Nishimura, M., Sako, T., Wada, Y., and Watanabe, Y.
A facile method for solid-phase conjugation of peptide with unprotected DOTA and synthesis of 68Ga-DOTA-somatostatin.
Peptide Science, 45th, 417-418, (2008).
Takahashi, K., Tamura, Y., Watanabe, Y., Långström, B., and Bergström, M.
Alteration in [11C]vorozole binding to aromatase in neuronal cells of rat brain induced by anabolic androgenic steroids and flutamide.
Neuroreport, 19(4): 431-435, 2008
Matsumoto K., Yamamoto S., Wada Y., Shimizu K., Murase K., Senda M.
Reliability of plural measuring instruments for quantitative PET measurement -performance of dose-calibrator, auto well gamma counter, continuous blood sampling system, and PET scanner.
日本放射線技術学会誌 64, 1224-34(2008)
渡辺恭良，鈴木正昭，尾上浩隆，土居久志，和田康弘，片岡洋祐，榎本秀一
分子イメージング研究における創薬・疾患診断の革新
最新医学 63, 116-138 (2008)
Cui, Y.L., Kataoka, Y., Inui, T., Mochizuki, T., Onoe, H., Matsumura, K., Urade, Y., Yamada, H. and Watanabe, Y.
Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats.
J Neurosci Res, 86 929-936 (2007)
Tamura, Y., Kataoka, Y., Cui, Y.L., Takamori, Y., Watanabe, Y. and Yamada, H.
Intracellular translocation of glutathione S-transferase pi during oligodendrocyte differentiation in adult rat cerebral cortex in vivo.
Neuroscience, 148, 535-540 (2007)
Takahashi, K., Hallberg, M., Magnusson, K., Nyberg, F., Watanabe, Y., Långström, B., and Bergström, M.
Inclease in [11C]Vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids.
NeuroReport, 18, 171-74 (2007)
Motomura, S., Enomoto, S., Haba, H., Igarashi, K., Gono, Y., and Yano, Y.
Gamma-Ray Compton Imaging of Multitracer in Biological Samples Using Strip Germanium Telescope
IEEE Transactions on Nuclear Science, 54, 710-717 (2007)
Cui, Y.L., Takamatsu, H., Kakiuchi, T., Ohba, H., Kataoka, Y., Yokoyama, C., Onoe, H., Watanabe, Yu., Hosoya, T., Suzuki, M., Noyori, R., Tsukada, H., and Watanabe, Y.
Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occulusion and reperfusion: A positron emission tomography study.
Stroke, 37, 2830-2836 (2006)
Kondo, S., Hosono, M.N., Wada, Y., Ishii, K., Matsumura, A., Takada, Y., Tashiro, M., Okamura, T., Fukuda, H., Yamada, R., Watanabe, Y., and Inoue, Y.
Use of FDG-microPET for detection of small nodules in a rabbit model of pulmonary metastatic cancer.
Ann. Nucl. Med. 18, 51-57 (2004)
Yamamoto, S., Ouchi, Y., Onoe, H., Yoshikawa, E., Tsukada, H., Takahashi, H., Iwase, M., Yamaguti, K., Kuratsune, H., and Watanabe, Y.
Reduction of serotonin transporters of patients with chronic fatigue syndrome.
Neuroreport 15, 2571-2574 (2004)
Matsumura, A., Mizokawa, S., Tanaka, M., Wada, Y., Nozaki, S., Nakamura, F., Shiomi, S., Ochi, H., and Watanabe, Y
Assessment of microPET performance in analyzing the rat brain under different types of anesthesia: Comparison between quantitative data obtained with microPET and ex vivo autoradiography.
NeuroImage 20, 2040-2050 (2003)
Kuratsune, H., Yamaguti, K., Lindh, G., Evengard, B., Hagberg, G., Matsumura, K., Iwase, M., Onoe, H., Machii, T., Kanakura, Y., Kitani, T., Langstrom, B., and Watanabe, Y.
Brain regions involved in fatigue sensation: Reduced acetylcarnitine uptake into the brain.
NeuroImage 17, 1256-1265 (2002)
Enblad, P., Frykholm, P., Valtysson, J., Silander, H.C., Andersson, J., Fasth, K.J., Watanabe, Y., Langstrom, B., Hilleled, L., and Persson, L.
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography
Stroke 32, 1574-1580 (2001)

学会発表

2010年
Excessive neural activation during divided attention processing in childhood chronic fatigue syndrome American Academy of Children & Adolescent Psychiatry (AACAP) 57th Annual Meeting, New York, Oct 26-31
2010年
Development of iterative reconstruction algorithm incorporating transaxial distance-dependent resolution compensation for small animal PET. Annual Congress of the European Association of Nuclear Medicine, Vienna, Austria, Oct 9-13
2010年
Developmental Changes in P-glycoprotein Function at the Blood-Brain Barrier of Non-Human Primates: PET Study with R-[11C]Verapamil. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010年
Evaluation of gastrointestinal drug absorption process after oral administration using positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and its rate limiting steps under anesthesia. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010年
64Cu-labeling of octreotide utilizing the N-terminal Cu binding motif (ATCUN). 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010年
In vivo monitoring of experimental arthritis using [11C]PK11195 and [11C]Ketoprofen before joint destruction. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010年
11C-Labeled cetrozole and its analogs: Excellent PET probes for aromatase. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010年
Detecting atherosclerotic plaques using PET and CT targeted p-selectin in mice. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010年
Evaluation of Serotonin Dynamics in the Brain of Functional Somatic Syndrome using Positron Emission Tomography. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010年
Amyloid plaque detection by using clinical magnetic field strength MRI. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010年
Evaluation of in vivo hepatobiliary transport using positron emittion tomography (PET): Studies in rats and application to microdosing clinical studies, International Society for the Study of Xenobiotics, Istanbul, Turkey, Sep 4-8
2009年
PET・SPECTを用いた実験データ解析
2009年
小動物PETを用いた機能イメージング
2008年
PET studies on the evaluation of multidrug resistance-associated protein 2 function in bliliary excreation.
2008年
Evaluation of sub-second duration dynamic PET images of mice.
2008年
Anabolic-androgenic steroid increases [11C]vorozole binding to aromatase in neurons of the hypothalamus in rat and rhesus
monkey.
2008年
固相上での簡便な無保護DOTAのペプチドへの修飾法と68Ga-DOTA-somatostatinの合成
2007年
Aromatase level altered by treatment of anabolic androgenic steroids is regulated through androgen receptor.
2007年
Attenuation effect of a rat for PET scanning.
2006年
A simple labeling method with Ga-68 for PET molecular imaging on peptides and proteins.
2006年
Evaluation and optimization of 3D MAP image reconstruction for microPET P4.

プレスリリース

受賞歴

2012年
日本小児神経学会 優秀論文賞(水野 敬)
2011年
日本DDS学会 優秀発表者賞(向井 英史)
2010年
第16回武田科学振興財団 生命科学シンポジウム 優秀ポスター賞(高橋 佳代)
2010年
文部科学大臣賞(渡辺 恭良)
2010年
Hiruma-Wagner award(高橋 佳代)
2008年
第54回大阪市長賞基礎医学部門(渡辺 恭良)
2008年
日本核医学会機関誌論文賞(渡辺 恭良)
2007年
第44回エルウイン・フォン・ベルツ賞1等賞(渡辺 恭良)